Effect of SHBG Polymorphism on the Levels of Bioavailable Testosterone and Lipid Metabolism in Older Men of the Kazakh Population

This study is aimed at investigating the effect of SHBG (rs727428; rs10822184) and LPL (rs754493647) single nucleotide polymorphisms on concentration bioavailable fraction testosterone in older men.
 Materials methods To gene mutations, 417 residents East Kazakhstan region Kazakh nationality were examined. The main group included 135 men with signs hypogonadism (AMS 37-49), control consisted 282 healthy 17-26) corresponding age (p = 0.5). Single rs 727428 [C / T]; rs10822184 [T C]; rs754493647 C], was determined by TaqMan method.
 Results Analysis rs727428 polymorphism has revealed that TT allele (rs727428) a lower level albumin 0.03), 0.04), free 0.6) than carriers CC CT genotypes. Also, it shown decrease total 0.001) an increase levels 0.07) genotype polymorphism. demonstrated triglyceride LDL ≤ comparison genotypes.
 Conclusion It been proven associated therefore can determine testosterone. Decreased are sign male hypogonadism. confirms 0.01) 0.04) levels, but its association androgen not proven. Our results may be interest for understanding etiology early development lipid metabolism disorders men. confirm conclusions, more detailed large sample from population required.